Click title to open manuscript .pdf
What we did: We investigated the metabolic response of the hagfish heart to anoxia using calorimetry to measure metabolic rate, and metabolite analyses to measure fuel use.
What we found: The hagfish heart’s metabolic rate remained at routine levels over 16+ hours of anoxia exposure despite depleting its predicted fuel source—glycogen—after ~8 hours.
What this means: The hagfish heart is an exceptionally tolerant organ and appears to rely on an as-yet-unknown fuel source to survive long-term anoxia exposure. This result could have only been revealed through a combination of calorimetry and metabolite analyses.